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doi:10.1016/j.regpep.2006.12.021 35

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Renal biopsy specimens from DKD patients reveal elevated expression of ferroptosis-associated proteinssuch as acyl-CoA synthetase long-chain family member 4 (ACSL4) and prostaglandin-endoperoxide synthase 2accompanied by marked downregulation of glutathione peroxidase 4 (GPX4), a key suppressor of ferroptosis (127)